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On September 6-9, 2016 the UNESCO Chair of Life Sciences International Postgraduate Educational Center organized the 9th EMF International Workshop: Bioelectromagnetics and Water Science to Aid Environmental Health Defence in Garni, Armenia.

Life Sciences International Postgraduate Educational Center is currently inviting young researchers to work and take PhD courses at LSIPEC

UNESCO Chair in Life Sciences will present the results of the research carried out in the Center in International Conferences
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2015 - present -  "The role of Na+/Ca2+ exchange in reverse mode in regulation of cell hydration"
Conclusion: The dysfunction of cAMP-dependent Na+/Ca2+ exchange in reverse mode is a primary mechanism for age-dependent cardio-muscle failure and memory impairment.

 

2014 - present -  "The role of age-dependent neuronal dehydartion in memory impairment"
Conclusion: The dysfunction of intracellular signaling system controlling cell hydration is responsible for age-dependent depression of neuronal function. 

 

2013 - present - “Bioremediation as a modern and efficient method for water pollution management”
Conclusion: H2O2-induced bactericide properties are elevated by non-critical concentration of CO2.

2013 - present – “Agrobiotechnology and food safety”
Conclusion 1: Extremely low frequency of electromagnetic field (ELF EMF)-treated water as a tool for the increase of growth and development of microbes and plants.
Conclusion 2: ELF EMF treatment as a novel method for the activation of bull sperm motility.
Conclusion 3: Double frequency of impedancemetric characteristics of meat is a novel method for determining its quality.

2010 - present –“The role of dysfunction  of α3 isoform-dependent signaling system controlling cell hydration in cancer generation”

Conclusion:  The dysfunction of α3 isoform of Na+/K+ pump is a primary mechanism for carcinogenesis.

2010 – present - “The study of the mechanism of age-dependent magneto- and microwave- sensitivity of rat brain and heart muscles in norm and pathology”

Conclusion: Age-dependent dysfunction of  Na+/K+ pump α3 isoform-dependent signaling system controlling cell hydration for the decrease of magnetosensitivity of heart muscle and brain tissue hydration.

2009 - present - “The study of functional role of different Na+/K+ pump isoforms in regulation of cell hydration in norm and pathology”
Conclusion: α3 isoform-dependent signaling system serves as a universal sensor through which the biological effect of weak environmental signals on cells and organisms are realized.

2008 - present – “Cellular and Molecular Mechanism of Biological Effect of Background Ionizing Radiation, Electro Magnetic Fields and Infrasound Frequency of Mechanical Vibration on Plants, Microbes, Invertebrate and Vertebrate Organisms”
Conclusion: Cell bathing aqua medium serves as one of the essential primary targets for biological effects of ionizing and non-ionizing radiation.

2007-present – “The role of the dysfunction of Na+/K+ Pump in age-dependent medical disorders”
Conclusion: Age-dependent dysfunction of α3 isoform-dependent signaling system controlling cell hydration serves as a primary mechanism for generation of age-related medical disorders.

2007-present - “The Correlation Between Brain Cell Hydration and Pain Sensation in mammals” 
Conclusion: Cell over-hydration promotes the nociceptive signals generation while dehydration has pain relief and anesthetic effects on mammals.

2007-present - “The Study of Cell Hydration as a Marker for Biological Effect of Environmental Factors”
Conclusion: Cell hydration serves as a universal and extrasensitive sensor for environmental factors in plants, microbes and mammals.

2001-present – “The Study of dependency of cell metabolic activity on cell bathing aqua structure”
Conclusion: - The environmental factor-induced changes in both water molecules disassociation and peroxide formation in cell bathing medium serve as messengers through which cell bathing medium could modulate its metabolic activity.

1998-2009 – “The study of low frequency of EMF and infrasound (IS) on physicochemical properties of water and peroxide formation”.
Conclusion:  EMF and IS have 4 and 8Hz frequency “windows” at which they have more pronounced effects on water molecules dissociation, heat fusion, electrical conductivity, gases solubility and hydrogen peroxide formation in water.

1997-2005 – “The nature of metabolic mechanism through which extremely weak chemical and physical factors can modulate conductive function (excitability and chemo sensitivity) of membrane" 
Conclusion: cGMP/cAMP dependent-Na:Ca exchanger serves as a universal and extrasensitive membrane sensor for extremely low concentrations of biologically active substances and weak physical factors.

1994- 2009 – “The role of structural changes of cell bathing aqua medium in realization of biological effects of non-ionizng radiation (electromagnetic fields and infrasound) on cells and organisms”.
Conclusion: EMF-induced changes of physicochemical properties and formation of ROS serve as main mechanisms through which non-thermal biological effects of magnetic and electrical fields on cells and organisms are realized.

1994-1997 - “The metabolic mechanism of the effect of NO on heart muscle contractility” (In collaboration with prof. Robert Walker, UK)
Conclusion: NO-induced heart muscle relaxation is due to the activation of cGMP-dependent Ca2+ efflux and Na+/Ca2+ exchange in forward mode from the cells.

1994-1997 – “The correlation between Na+/Ca2+ exchange and intracellular cAMP/cGMP”
Conclusion: Intracellular cGMP plays a key role in the activation of Ca efflux through Na+/Ca2+exchange in forward mode and Ca pump mechanisms, while intracellular cAMP activates Ca influx by
Na+/Ca2+ exchange in reverse mode.

1990-1998 - “Biological effect of extremely low concentrations of transmitters on membrane functional activity”. (In collaboration with David Carpenter, USA, Robert Walker, UK, Peter Usherwood, UK, Yanosh Salanki, Hungary)
Conclusion: Low concentration having no effect on membrane conductive properties regulate the conductive function of membrane through modulatation of intracellular signaling system. 

1989-1990 – “Metabolic regulation of N-cholinoreceptor affinity”
Conclusion: Inactivation of Na-pump leads to the increase of number of functionally active chemoreceptors in membrane and the decrease of their affinity to ligands.

1988-1989 – “Correlation between Na+/K+ pump activity and intracellular contents of cAMP”
Conclusion: Pump inactivation leads to the increase of intracellular cAMP contents while its activation has the opposite effect.

1987 – 1991 - “The study of the functional role of Na+/K+ pump in regulation with cell sensitivity to ionizing radiation” (in collaboration with Dvoretsky A.I., Shainskaya A.M., Ukraine)
Conclusion: Ionic radiation-induced Na+/K+ pump inhibition leads to the increase of the number of pump units in the membrane. High affinity ouabain receptors have higher sensitivity to ionizing radiation than low affinity receptors.

1986-1988 – “Correlation between Na+/K+ pump activity and Na+/Ca2+ exchange”
Conclusion: There is a negative correlation between Na+/K+ pump and Na+/Ca2+ exchange activity that is realized by intracellular level of cAMP.

1984-1992 - “The study of the role of lipid composition in regulation of membrane protein function” (In collaboration with Prof. Toshifumi Takenaka, Japan)
Conclusion: Short-chain fatty acids can be effective modulators of both ouabain-sensitive and ouabain-insensitive fractions of Na+ efflux from the cells, membrane excitability and chemosensitivity.

1984-1991 – “The ionic membrane mechanism of ionizing radiation on neuromembrane function”.

Conclusion: Ca2+-dependent activation of Lipase A2 activity is the gate of ionizing radiation of membrane damage (In collaboration with prof. Konstantin Karageuzyan, Armenia)

1980-1987 “The role of membrane lipid surrounding in regulation the functional activity of membrane protein”
Conclusion: The negative correlation between Na+/K+ pump and Na+/Ca2+ exchange depends on membrane lipids’ fluidity. The increase of the latter leads to disappearance of the mentioned correlation. Decanoid acid- induced membrane fluidity leads to the activation of the agonist-induced K+ currents.

1980-1988 - “The effect of water fluxes through the membrane on transmembrane characters” (In collaboration with Prof. Kiozo Koketsu, Japan)
Conclusion: Transmembrane water fluxes having activation effect on membrane current have the same direction and inactivation effect on current having opposite direction.

1977-1984 – “The study of the functional role of electrogenic Na+/K+ pump in regulation of cell volume”
Conclusion: Na+/K+ pump has a cell volume regulation function: its activation leads to the shrinkage while inactivation to cell swelling.

1980-1990 – “The study of functional role of pump-induced cell volume changes in regulation of membrane chemo sensitivity and excitability”
Conclusion: Number of functionally active protein molecules having enzymatic chemoreceptive and ion channel forming properties depend on cell surface: surface increasing leads to elevation of number of functional active proteins while shrinkage has the opposite effect.

1969-1976 “The mechanism regulating pacemaker activity of Helix neurons” (In collaboration with prof. Howard Wachtell, USA)
Conclusion: The oscillation of electrogenic sodium pump-dependent cell volume is responsible for membrane potential oscillation of pacemaker neurons.

1965-1969 – “The study of the role of cell metabolic processes in generation of membrane potential of snail neuron”. (postgraduate thesis, advisor- Prof. Platon Kostyuk, Ukraine)
Conclusion: The resting potential of snail neurons consists of two components of different nature: the first is purely diffused, and is due to the presence of ionic gradient on the membrane, the second is generated by electrogenic sodium pump.